Technologies

™Technology Platform
Precision Novasperse™ (Nanoparticle) Technology
Modified Release Coating & Surface Enhancement Technologies

PharmaNova’s Precision Novasperse™ Technology (PNT): providing new opportunities for poorly soluble drugs.

PharmaNova’s nanoparticle technology offers the potential for numerous fast-to-market products. Many APIs  and potential drugs are so poorly soluble in water that bioavailability is significantly reduced and some routes of administration are not feasible without chemical modification of the API or the addition of potentially harmful solubilizing agents. Nanoparticle technology is one of the most exciting developments in pharmaceutical formulation science in decades and PharmaNova expects to be a world leader in its application to pharmaceuticals.  The reduction of particles to sub-micron dimensions introduces dramatic changes in the physico-chemical properties of compounds enabling many formulation and delivery options previously not feasible.

Key Features:
• Spherical amorphous nanoparticles of the active pharmaceutical ingredient (API)
• Particle sizes from 25nM to 10µM
• Narrow particle size range around the mean
• Highly scaleable process from laboratory to manufacture
• Compatible with many formulation and delivery systems

PharmaNova’s nanoparticle platform has been well validated by the early development of numerous prototype products, ready for clinical development and available for licensing. 

Modified Release Coating Technology

Our proprietary modified release coating technology offers the capability for

• Single and multi-phasic release profiles
• Targeting for selective sites for systemic absorption from the G-I tract
• Targeting for precise delivery to sites for local activity within the G-I tract
• Ease of swallowing

 Dysphagia

Dysphagia (swallowing difficulty) is commonly associated with aging and can be precipitated by Stroke, Parkinson’s Disease, dementia, thyroid enlargement, esophageal cancer, and many other conditions.  There are many pharmaceutical products that are inherently difficult to swallow due to size, shape, surface properties etc. and PharmaNova’s SET film coatings are designed to facilitate swallowing of a wide range of medications for many patient groups.

Key features:
• Biocompatible safe lubricious film coatings
• Utilize body fluids or aqueous media to reduce frictional forces by more than 90%
• Formulation enhancement with no effect on dissolution profiles
• Applicable to solid oral dosage forms of wide range of size and shape.
• Ease of swallowing and rapid esophageal transit.